South African award-winning actor and fashion designer is known for her breakthrough role on the South African television series, Tshisa 2006. Mlotshwa landed her first role on the South African series Mtunzini.com which aired on the South African National Broadcasting Corporation from 2006 - 2009. Mlotshwa has since been cast on numerous South African television soapies and drama series including the telenovela iNkaba, Moferefere Lenyalong, Soul City, Sokhulu and Partners, Rhythm City, Rockville, and 7de Laan.
She launched the maternity wear range SE Preggoz in South Africa and New York in 2015.
In 2009, Mlotshwa hosted the Channel O series, Young, Gifted and Black and then went on to host ANN7’s, Starbiz which focused on local and international entertainment news. She was a speaker at the Dstv In Good Company Experience which hosted American actor and writer, Issa Rae in 2018.
In 2018, she was cast as the lead actor in the short film Lace. The film won Best Film, Audience Favourite, Best Actor, Best Writing, Best Directing, and Best Special Effects for the 48 Hour Film Project in Johannesburg. The film went on to compete at Filmapalooza 2019 in Orlando, Florida and earned Mlotshwa an international Best Actress Award.
In 2019, Mlotshwa was cast as supporting lead for the series The Herd as well as lead in iSibaya. Enhle is a South African lead actor performing in Loving Thokoza, Slay, U’Hambo and more recently, A Safe Bet.