She was born in Vrede, Free State, South Africa. She is named after her paternal grandmother. Xolile graduated from the National School of the Arts with honours and as well as the award for 'Best Overall Performer'.
During her studies at the NSA, Xolile had the opportunity to play alongside Thembi Mtshali-Jones, where she became her mentor. They performed together in the play The Crucible shown at The Market Theatre. She has also starred in many television productions such Soul City S7, where she played sister Zama. Not limited to on-screen acting, Xolile has also starred in various plays which include ‘Another Child’.
From 2002 to 2005 she starred in the television hit serial Generations. She played the role Julia Montene, who became highly popular among the public. In 2007, she joined with NCIS S5 as 'Sayda Zuri', in the episode titled Designated Target. With the success in her roles, she became a household name in SA and went on to star in television productions such as Secret in my Bosom, Scoop Schoombie, Justice for All and Isidingo.
In 2008 she went to the United States to attend New York Film Academy. She returned to South Africa in 2010 and played the role 'Noma' in the television serial 4Play: Sex Tips for Girls. Then she played the role of 'Mandi Mbalula' in the serial Fallen, a 2011 drama series. In 2013, Xolile appeared as 'Gugu' in High Rollers which aired on SABC 3.
In 2020 Xolile starred as supporting lead in Housekeepers and she played the role 'Nwabisa Bhele' in the Netflix original series Blood & Water. The series became one of the most rated television serials in South Africa. More recently, Xolile starred in the highly successful Netflix production, Happiness Ever After and the play, Raisin The Sun.